Plasticity in current-driven vortex lattices

We present a theoretical analysis of recent experiments on current-driven vortex dynamics in the Corbino disk geometry. This geometry introduces controlled spatial gradients in the driving force and allows the study of the onset of plasticity and tearing in clean vortex lattices. We describe plastic slip in terms of the stress-driven unbinding of dislocation pairs, which in turn contribute to the relaxation of the shear, yielding a nonlinear response. The steady state density of free dislocations induced by the applied stress is calculated as a function of the applied current and temperature. A criterion for the onset of plasticity at a radial location $r$ in the disk yields a temperature-dependent critical current that is in qualitative agreement with experiments.Comment: 11 pages, 4 figure

Peak effect in twinned superconductors

A sharp maximum in the critical current $J_c$ as a function of temperature just below the melting point of the Abrikosov flux lattice has recently been observed in both low and high temperature superconductors. This peak effect is strongest in twinned crystals for fields aligned with the twin planes. We propose that this peak signals the breakdown of the collective pinning regime and the crossover to strong pinning of single vortices on the twin boundaries. This crossover is very sharp and can account for the steep drop of the differential resistivity observed in experiments.Comment: 4 pages, revtex 3.0, no figure

Spontaneous patterns in coherently driven polariton microcavities

We consider a polariton microcavity resonantly driven by two external lasers which simultaneously pump both lower and upper polariton branches at normal incidence. In this setup, we study the occurrence of instabilities of the pump-only solutions towards the spontaneous formation of patterns. Their appearance is a consequence of the spontaneous symmetry breaking of translational and rotational invariance due to interaction induced parametric scattering. We observe the evolution between diverse patterns which can be classified as single-pump, where parametric scattering occurs at the same energy as one of the pumps, and as two-pump, where scattering occurs at a different energy. For two-pump instabilities, stripe and chequerboard patterns become the dominant steady-state solutions because cubic parametric scattering processes are forbidden. This contrasts with the single-pump case, where hexagonal patterns are the most common arrangements. We study the possibility of controlling the evolution between different patterns. Our results are obtained within a linear stability analysis and are confirmed by finite size full numerical calculations.Comment: 15 pages, 9 figure

Models of plastic depinning of driven disordered systems

Two classes of models of driven disordered systems that exhibit history-dependent dynamics are discussed. The first class incorporates local inertia in the dynamics via nonmonotonic stress transfer between adjacent degrees of freedom. The second class allows for proliferation of topological defects due to the interplay of strong disorder and drive. In mean field theory both models exhibit a tricritical point as a function of disorder strength. At weak disorder depinning is continuous and the sliding state is unique. At strong disorder depinning is discontinuous and hysteretic.Comment: 3 figures, invited talk at StatPhys 2

Driven depinning of strongly disordered media and anisotropic mean-field limits

Extended systems driven through strong disorder are modeled generically using coarse-grained degrees of freedom that interact elastically in the directions parallel to the driving force and that slip along at least one of the directions transverse to the motion. A realization of such a model is a collection of elastic channels with transverse viscous couplings. In the infinite range limit this model has a tricritical point separating a region where the depinning is continuous, in the universality class of elastic depinning, from a region where depinning is hysteretic. Many of the collective transport models discussed in the literature are special cases of the generic model.Comment: 4 pages, 2 figure

Predictive biomarkers for checkpoint inhibitor-based immunotherapy: The Galectin-3 signature in NSCLCs

Checkpoint inhibitor-based immunotherapy is opening a promising scenario in oncology, with objective responses registered in multiple cancer types. However, reliable predictive markers of tumor responsiveness are still lacking. These markers need to be urgently identified for a better selection of patients that can be candidates for immunotherapy. In this pilot study, a cohort of 34 consecutive patients bearing programmed death-ligand 1 (PD-L1)-positive non-small cell lung carcinoma (NSCLC), treated with pembrolizumab, was considered. The retrospective immuno-phenotypic analysis performed on the original tumor biopsies allowed for the identification of a specific “galectin signature”, which strongly correlated with tumor responsiveness to anti PD-1 immunotherapy. We observed that the large majority of patients (about 90%) with high galectin-3 tumor expression (score 3+) showed an early and dramatic progression of the disease after three cycles of treatments. In contrast, all patients with negative or low/intermediate expression of galectin-3 in tumor cells showed an early and durable objective response to pembrolizumab, indicating galectin-3 as an interesting predictive marker of tumor responsiveness. The galectin-3 signature, at least in NSCLCs, promises a better selection of patient candidates for immunotherapy, reducing unnecessary treatment exposures and social costs. A large multicenter study is ongoing to validate this finding

Translational Correlations in the Vortex Array at the Surface of a Type-II Superconductor

We discuss the statistical mechanics of magnetic flux lines in a finite-thickness slab of type-II superconductor. The long wavelength properties of a flux-line liquid in a slab geometry are described by a hydrodynamic free energy that incorporates the boundary conditions on the flux lines at the sample's surface as a surface contribution to the free energy. Bulk and surface weak disorder are modeled via Gaussian impurity potentials. This free energy is used to evaluate the two-dimensional structure factor of the flux-line tips at the sample surface. We find that surface interaction always dominates in determining the decay of translational correlations in the asymptotic long-wavelength limit. On the other hand, such large length scales have not been probed by the decoration experiments. Our results indicate that the translational correlations extracted from the analysis of the Bitter patterns are indeed representative of behavior of flux lines in the bulk.Comment: 23 pages, 1 figure (not included), harvmac.tex macro needed (e-mail requests to [email protected] SU-CM-92-01